BRD-A94413429_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-A94413429_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAT2 acetyl-CoA acetyltransferase 2
ACBD3 acyl-CoA binding domain containing 3
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
ANXA3 annexin A3
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF1 chromosome 14 open reading frame 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COMP cartilage oligomeric matrix protein
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FST follistatin
G6PD glucose-6-phosphate dehydrogenase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GM2A GM2 ganglioside activator
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA1 high mobility group AT-hook 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IGFBP4 insulin-like growth factor binding protein 4
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KLF6 Kruppel-like factor 6
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MID1IP1 MID1 interacting protein 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MYO6 myosin VI
NAV2 neuron navigator 2
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSDHL NAD(P) dependent steroid dehydrogenase-like
PAM peptidylglycine alpha-amidating monooxygenase
PDLIM4 PDZ and LIM domain 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNPLA3 patatin-like phospholipase domain containing 3
PNRC1 proline-rich nuclear receptor coactivator 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAP1GAP RAP1 GTPase activating protein
RBPMS RNA binding protein with multiple splicing
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1 runt-related transcription factor 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
STC2 stanniocalcin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF217 zinc finger protein 217
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CXCL12 chemokine (C-X-C motif) ligand 12
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMBT1 deleted in malignant brain tumors 1
DST dystonin
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FAM107A family with sequence similarity 107, member A
FANCI Fanconi anemia, complementation group I
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBP1 guanylate binding protein 1, interferon-inducible
GRWD1 glutamate-rich WD repeat containing 1
HIST1H4C histone cluster 1, H4c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
MT1E metallothionein 1E
MT1M metallothionein 1M
MT1X metallothionein 1X
NCAPG non-SMC condensin I complex, subunit G
NDRG2 NDRG family member 2
NEK2 NIMA-related kinase 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
SMC2 structural maintenance of chromosomes 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
UBL5 ubiquitin-like 5