BRD-A94377914_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

338 genes differentially expressed following the BRD-A94377914_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACO1 aconitase 1, soluble
ACOT7 acyl-CoA thioesterase 7
AK1 adenylate kinase 1
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANOS1 anosmin 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALCOCO1 calcium binding and coiled-coil domain 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL20 chemokine (C-C motif) ligand 20
CCNE1 cyclin E1
CCNG2 cyclin G2
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLIC5 chloride intracellular channel 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CRAT carnitine O-acetyltransferase
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
DPYSL2 dihydropyrimidinase-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESYT1 extended synaptotagmin-like protein 1
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FAM162A family with sequence similarity 162, member A
FBLN5 fibulin 5
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GATA6 GATA binding protein 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GSDMB gasdermin B
GSN gelsolin
HECA headcase homolog (Drosophila)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IL17RB interleukin 17 receptor B
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
KIF3C kinesin family member 3C
L1CAM L1 cell adhesion molecule
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGST3 microsomal glutathione S-transferase 3
MID1 midline 1
MLF1 myeloid leukemia factor 1
MOSPD1 motile sperm domain containing 1
MSRB1 methionine sulfoxide reductase B1
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PGK1 phosphoglycerate kinase 1
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB29 RAB29, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SCRG1 stimulator of chondrogenesis 1
SEPT6 septin 6
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMTN smoothelin
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STAB1 stabilin 1
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ADNP activity-dependent neuroprotector homeobox
AGR2 anterior gradient 2
AKAP8 A kinase (PRKA) anchor protein 8
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA10 annexin A10
ARID1A AT rich interactive domain 1A (SWI-like)
ASPN asporin
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CSTA cystatin A (stefin A)
CTBP1 C-terminal binding protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTD dCMP deaminase
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DST dystonin
DUT deoxyuridine triphosphatase
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESR1 estrogen receptor 1
FAM20B family with sequence similarity 20, member B
FAM57A family with sequence similarity 57, member A
FBXO11 F-box protein 11
FKBP11 FK506 binding protein 11, 19 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS2 growth arrest-specific 2
GATA3 GATA binding protein 3
GATAD1 GATA zinc finger domain containing 1
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
GSAP gamma-secretase activating protein
GTPBP8 GTP-binding protein 8 (putative)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIRA histone cell cycle regulator
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IL1RN interleukin 1 receptor antagonist
IRAK1 interleukin-1 receptor-associated kinase 1
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KAT6B K(lysine) acetyltransferase 6B
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIF18B kinesin family member 18B
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LMNB1 lamin B1
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MLPH melanophilin
MREG melanoregulin
MRPS18B mitochondrial ribosomal protein S18B
MRPS30 mitochondrial ribosomal protein S30
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NBN nibrin
NFE2L2 nuclear factor, erythroid 2-like 2
NINJ1 ninjurin 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRR11 proline rich 11
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SCRN1 secernin 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TCERG1 transcription elongation regulator 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TLK2 tousled-like kinase 2
TM4SF1 transmembrane 4 L six family member 1
TRIM29 tripartite motif containing 29
TTC39A tetratricopeptide repeat domain 39A
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE3A ubiquitin protein ligase E3A
UPK1B uroplakin 1B
USP22 ubiquitin specific peptidase 22
VCAN versican
WDR43 WD repeat domain 43
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF512B zinc finger protein 512B
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721