BRD-A93236127_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A93236127_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
APLP2 amyloid beta (A4) precursor-like protein 2
APOLD1 apolipoprotein L domain containing 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
C2CD2 C2 calcium-dependent domain containing 2
CA1 carbonic anhydrase I
CCL19 chemokine (C-C motif) ligand 19
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CPM carboxypeptidase M
CYR61 cysteine-rich, angiogenic inducer, 61
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR1 early growth response 1
FGFR2 fibroblast growth factor receptor 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
IER2 immediate early response 2
IER3 immediate early response 3
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MSMB microseminoprotein, beta-
MT1G metallothionein 1G
MXI1 MAX interactor 1, dimerization protein
NFE2L2 nuclear factor, erythroid 2-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSPH phosphoserine phosphatase
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGIF1 TGFB-induced factor homeobox 1
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D1 TSC22 domain family, member 1
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VWF von Willebrand factor
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CHGB chromogranin B
CSRP1 cysteine and glycine-rich protein 1
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
EIF5 eukaryotic translation initiation factor 5
ELOVL2 ELOVL fatty acid elongase 2
FAM134B family with sequence similarity 134, member B
FAP fibroblast activation protein, alpha
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LDHA lactate dehydrogenase A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAT2A methionine adenosyltransferase II, alpha
MYH11 myosin, heavy chain 11, smooth muscle
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY neuropeptide Y
NUP62 nucleoporin 62kDa
PLN phospholamban
PPA1 pyrophosphatase (inorganic) 1
PRUNE2 prune homolog 2 (Drosophila)
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPT9 septin 9
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS2 thrombospondin 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIM14 tripartite motif containing 14
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
XBP1 X-box binding protein 1
ZW10 zw10 kinetochore protein