BRD-A93236127_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-A93236127_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AEBP1 AE binding protein 1
APOLD1 apolipoprotein L domain containing 1
ARHGAP29 Rho GTPase activating protein 29
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
BLNK B-cell linker
CA1 carbonic anhydrase I
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DIO1 deiodinase, iodothyronine, type I
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EVI2A ecotropic viral integration site 2A
FBN2 fibrillin 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GOLT1B golgi transport 1B
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HIST1H2BG histone cluster 1, H2bg
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM6B lysine (K)-specific demethylase 6B
KRT6A keratin 6A, type II
KRT8 keratin 8, type II
LUM lumican
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MT1E metallothionein 1E
NET1 neuroepithelial cell transforming 1
NKX2-1 NK2 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPL1 nucleoporin like 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SGK1 serum/glucocorticoid regulated kinase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SRSF7 serine/arginine-rich splicing factor 7
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNT1 troponin T type 1 (skeletal, slow)
TRA2A transformer 2 alpha homolog (Drosophila)
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACACB acetyl-CoA carboxylase beta
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ATMIN ATM interactor
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CRISP3 cysteine-rich secretory protein 3
CXCL5 chemokine (C-X-C motif) ligand 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIXDC1 DIX domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DMXL1 Dmx-like 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP4 dual specificity phosphatase 4
FCGBP Fc fragment of IgG binding protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSPT2 G1 to S phase transition 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGBP1 immunoglobulin (CD79A) binding protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KEAP1 kelch-like ECH-associated protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY75 lymphocyte antigen 75
MCAM melanoma cell adhesion molecule
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
NDRG2 NDRG family member 2
NLGN4X neuroligin 4, X-linked
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PROM1 prominin 1
PSCA prostate stem cell antigen
PSD3 pleckstrin and Sec7 domain containing 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPA1 replication protein A1, 70kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SORBS1 sorbin and SH3 domain containing 1
SPATA20 spermatogenesis associated 20
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM47 transmembrane protein 47
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)