BRD-A90643929_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A90643929_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CPM carboxypeptidase M
CST1 cystatin SN
CTSK cathepsin K
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EAF2 ELL associated factor 2
ECM1 extracellular matrix protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FN1 fibronectin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ISG20 interferon stimulated exonuclease gene 20kDa
KRT23 keratin 23, type I
LRMP lymphoid-restricted membrane protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SQSTM1 sequestosome 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
UFM1 ubiquitin-fold modifier 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ASCL1 achaete-scute family bHLH transcription factor 1
BST2 bone marrow stromal cell antigen 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CNPY3 canopy FGF signaling regulator 3
EFNB2 ephrin-B2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HAPLN1 hyaluronan and proteoglycan link protein 1
HSPB8 heat shock 22kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LY6D lymphocyte antigen 6 complex, locus D
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PLAC8 placenta-specific 8
PTGES prostaglandin E synthase
SCEL sciellin
SELL selectin L
SH3BP4 SH3-domain binding protein 4
SOX11 SRY (sex determining region Y)-box 11
TGM2 transglutaminase 2
TNC tenascin C
TNS1 tensin 1
TREM1 triggering receptor expressed on myeloid cells 1
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6