BRD-A90451247_KU-60019_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-A90451247_KU-60019_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BZW2 basic leucine zipper and W2 domains 2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
FPR1 formyl peptide receptor 1
FUCA1 fucosidase, alpha-L- 1, tissue
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GRN granulin
GRWD1 glutamate-rich WD repeat containing 1
GSN gelsolin
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
ITGAV integrin, alpha V
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5B lysine (K)-specific demethylase 5B
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKSL1 MARCKS-like 1
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PI3 peptidase inhibitor 3, skin-derived
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC38A2 solute carrier family 38, member 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
STK26 serine/threonine protein kinase 26
TM7SF2 transmembrane 7 superfamily member 2
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AUTS2 autism susceptibility candidate 2
BUB3 BUB3 mitotic checkpoint protein
CASP1 caspase 1, apoptosis-related cysteine peptidase
CETN3 centrin, EF-hand protein, 3
COPS7A COP9 signalosome subunit 7A
CRIP2 cysteine-rich protein 2
DFNA5 deafness, autosomal dominant 5
DLD dihydrolipoamide dehydrogenase
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FRY furry homolog (Drosophila)
GPI glucose-6-phosphate isomerase
GYPC glycophorin C (Gerbich blood group)
HIST1H4C histone cluster 1, H4c
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HOXC10 homeobox C10
KRT23 keratin 23, type I
MELK maternal embryonic leucine zipper kinase
MME membrane metallo-endopeptidase
NUP85 nucleoporin 85kDa
PDLIM1 PDZ and LIM domain 1
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PROSC proline synthetase co-transcribed homolog (bacterial)
RHOBTB3 Rho-related BTB domain containing 3
SFRP1 secreted frizzled-related protein 1
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
STMN1 stathmin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TUSC3 tumor suppressor candidate 3
VDAC3 voltage-dependent anion channel 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZW10 zw10 kinetochore protein