BRD-A90451247_KU-60019_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A90451247_KU-60019_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
APOC1 apolipoprotein C-I
BHLHE41 basic helix-loop-helix family, member e41
BZW2 basic leucine zipper and W2 domains 2
CES1 carboxylesterase 1
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
COL9A3 collagen, type IX, alpha 3
CTSA cathepsin A
DDIT3 DNA-damage-inducible transcript 3
DHCR24 24-dehydrocholesterol reductase
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPCAM epithelial cell adhesion molecule
FADS1 fatty acid desaturase 1
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HMOX1 heme oxygenase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KAZN kazrin, periplakin interacting protein
LCN2 lipocalin 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAST2 microtubule associated serine/threonine kinase 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1F metallothionein 1F
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRL platelet-derived growth factor receptor-like
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PRNP prion protein
PROM1 prominin 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPCT glutaminyl-peptide cyclotransferase
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STX3 syntaxin 3
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
CDC42 cell division cycle 42
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFBP1 fibroblast growth factor binding protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB6 homeobox B6
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NIT1 nitrilase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
PXMP2 peroxisomal membrane protein 2, 22kDa
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SPRED2 sprouty-related, EVH1 domain containing 2
TUBB2A tubulin, beta 2A class IIa
ZFP36L2 ZFP36 ring finger protein-like 2