BRD-A90451247_KU-60019_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-A90451247_KU-60019_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNG1 cyclin G1
CD44 CD44 molecule (Indian blood group)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EFS embryonal Fyn-associated substrate
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
G0S2 G0/G1 switch 2
GPNMB glycoprotein (transmembrane) nmb
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDS iduronate 2-sulfatase
ITM2A integral membrane protein 2A
LGALS3 lectin, galactoside-binding, soluble, 3
MAX MYC associated factor X
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
PAX8 paired box 8
PLAC8 placenta-specific 8
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SUSD4 sushi domain containing 4
SYK spleen tyrosine kinase
TCTN1 tectonic family member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM255A transmembrane protein 255A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VGLL4 vestigial-like family member 4
VIM vimentin

decreased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BIRC5 baculoviral IAP repeat containing 5
BZW2 basic leucine zipper and W2 domains 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPT dermatopontin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GRWD1 glutamate-rich WD repeat containing 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HOPX HOP homeobox
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MELK maternal embryonic leucine zipper kinase
NPY neuropeptide Y
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTTG1 pituitary tumor-transforming 1
SELENBP1 selenium binding protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN4 tetraspanin 4
ZMYM2 zinc finger, MYM-type 2