BRD-A90451247_KU-60019_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-A90451247_KU-60019_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGA aspartylglucosaminidase
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ARF1 ADP-ribosylation factor 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP10B ATPase, class V, type 10B
BEX4 brain expressed, X-linked 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
BZW2 basic leucine zipper and W2 domains 2
C14ORF1 chromosome 14 open reading frame 1
CA9 carbonic anhydrase IX
CCNG2 cyclin G2
CD38 CD38 molecule
CHRDL1 chordin-like 1
CRABP2 cellular retinoic acid binding protein 2
CYBA cytochrome b-245, alpha polypeptide
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAZAP2 DAZ associated protein 2
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KLF5 Kruppel-like factor 5 (intestinal)
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR2 lysophosphatidic acid receptor 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NSDHL NAD(P) dependent steroid dehydrogenase-like
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAIP1 poly(A) binding protein interacting protein 1
PANK3 pantothenate kinase 3
PCDH9 protocadherin 9
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRUNE2 prune homolog 2 (Drosophila)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERINC5 serine incorporator 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18 solute carrier family 22, member 18
SOCS2 suppressor of cytokine signaling 2
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TCEAL4 transcription elongation factor A (SII)-like 4
TM7SF2 transmembrane 7 superfamily member 2
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ARMCX6 armadillo repeat containing, X-linked 6
ASPN asporin
ASRGL1 asparaginase like 1
CDA cytidine deaminase
CDC42 cell division cycle 42
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBLN1 fibulin 1
FGB fibrinogen beta chain
FLNA filamin A, alpha
GRWD1 glutamate-rich WD repeat containing 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
IQGAP2 IQ motif containing GTPase activating protein 2
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM4 minichromosome maintenance complex component 4
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MRPL15 mitochondrial ribosomal protein L15
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NXN nucleoredoxin
PFDN4 prefoldin subunit 4
PODXL podocalyxin-like
PRKCH protein kinase C, eta
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC2 replication factor C (activator 1) 2, 40kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
RSL1D1 ribosomal L1 domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPRSS3 transmembrane protease, serine 3
TUBB2A tubulin, beta 2A class IIa
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
ZNF83 zinc finger protein 83