BRD-A89337244_PD 102807_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-A89337244_PD 102807_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK6 cyclin-dependent kinase 6
CLIC4 chloride intracellular channel 4
COL16A1 collagen, type XVI, alpha 1
COLEC12 collectin sub-family member 12
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DOK5 docking protein 5
ELAVL1 ELAV like RNA binding protein 1
EMP1 epithelial membrane protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS isoleucyl-tRNA synthetase
IDI1 isopentenyl-diphosphate delta isomerase 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
PRTN3 proteinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN2 stathmin 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TPM4 tropomyosin 4
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCL19 chemokine (C-C motif) ligand 19
CCR2 chemokine (C-C motif) receptor 2
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLU clusterin
COCH cochlin
CRIP2 cysteine-rich protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DNASE1L3 deoxyribonuclease I-like 3
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
MDK midkine (neurite growth-promoting factor 2)
NELL2 NEL-like 2 (chicken)
NPY1R neuropeptide Y receptor Y1
NXN nucleoredoxin
PDE2A phosphodiesterase 2A, cGMP-stimulated
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBM34 RNA binding motif protein 34
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOB1 transducer of ERBB2, 1
TSPAN4 tetraspanin 4
UGCG UDP-glucose ceramide glucosyltransferase
VAMP8 vesicle-associated membrane protein 8