BRD-A87137733_GSK-690693_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-A87137733_GSK-690693_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CHN1 chimerin 1
CNN3 calponin 3, acidic
COCH cochlin
COL1A2 collagen, type I, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DST dystonin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
FGFR2 fibroblast growth factor receptor 2
FOXO1 forkhead box O1
GPC4 glypican 4
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MTUS1 microtubule associated tumor suppressor 1
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
OLFM4 olfactomedin 4
OSBPL9 oxysterol binding protein-like 9
P3H2 prolyl 3-hydroxylase 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCP4 Purkinje cell protein 4
PLS1 plastin 1
PPL periplakin
PROS1 protein S (alpha)
R3HDM2 R3H domain containing 2
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SAP30 Sin3A-associated protein, 30kDa
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAV3 vav 3 guanine nucleotide exchange factor
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAM12 ADAM metallopeptidase domain 12
AGTR1 angiotensin II receptor, type 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ASPN asporin
ATXN1 ataxin 1
BHLHE40 basic helix-loop-helix family, member e40
CCND1 cyclin D1
CLEC11A C-type lectin domain family 11, member A
COL1A1 collagen, type I, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK1E casein kinase 1, epsilon
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CYB561 cytochrome b561
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HMGA2 high mobility group AT-hook 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LGALS1 lectin, galactoside-binding, soluble, 1
LIMA1 LIM domain and actin binding 1
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MFAP2 microfibrillar-associated protein 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLAUR plasminogen activator, urokinase receptor
PTHLH parathyroid hormone-like hormone
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SLC43A3 solute carrier family 43, member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1