BRD-A87137733_GSK-690693_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-A87137733_GSK-690693_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSF2 acyl-CoA synthetase family member 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD36B ankyrin repeat domain 36B
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
C14ORF132 chromosome 14 open reading frame 132
CA4 carbonic anhydrase IV
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD81 CD81 molecule
CELF2 CUGBP, Elav-like family member 2
CHRDL1 chordin-like 1
CLDN8 claudin 8
CLU clusterin
CRYAB crystallin, alpha B
EFHD1 EF-hand domain family, member D1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM102A family with sequence similarity 102, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
KLHDC2 kelch domain containing 2
KRT7 keratin 7, type II
LBH limb bud and heart development
LEFTY1 left-right determination factor 1
LITAF lipopolysaccharide-induced TNF factor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MGLL monoglyceride lipase
MVP major vault protein
NCOA2 nuclear receptor coactivator 2
NEFH neurofilament, heavy polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OXTR oxytocin receptor
PADI2 peptidyl arginine deiminase, type II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PLAGL1 pleiomorphic adenoma gene-like 1
PNMAL1 paraneoplastic Ma antigen family-like 1
QPRT quinolinate phosphoribosyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BGRL SH3 domain binding glutamate-rich protein like
TGFBR3 transforming growth factor, beta receptor III
TSPYL5 TSPY-like 5
VIPR1 vasoactive intestinal peptide receptor 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
BZW1 basic leucine zipper and W2 domains 1
CALR calreticulin
CALU calumenin
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD58 CD58 molecule
CDC42 cell division cycle 42
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFI complement factor I
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELANE elastase, neutrophil expressed
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM198B family with sequence similarity 198, member B
FAM3C family with sequence similarity 3, member C
FAT1 FAT atypical cadherin 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
KLK10 kallikrein-related peptidase 10
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIF leukemia inhibitory factor
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MCFD2 multiple coagulation factor deficiency 2
MCL1 myeloid cell leukemia 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MRPL42 mitochondrial ribosomal protein L42
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
ODC1 ornithine decarboxylase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZEB1 zinc finger E-box binding homeobox 1