BRD-A84524947_1-(3,4-bis(benzyloxy)-2,5-difluorophenyl)-2-(methylamino)ethanol KLK-37_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-A84524947_1-(3,4-bis(benzyloxy)-2,5-difluorophenyl)-2-(methylamino)ethanol KLK-37_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADIRF adipogenesis regulatory factor
BTG2 BTG family, member 2
C1ORF115 chromosome 1 open reading frame 115
CD163 CD163 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPVL carboxypeptidase, vitellogenic-like
CTSB cathepsin B
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
GLUL glutamate-ammonia ligase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
INSIG1 insulin induced gene 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
LMO4 LIM domain only 4
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NGRN neugrin, neurite outgrowth associated
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PIR pirin (iron-binding nuclear protein)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRBP1 ribosome binding protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TNS1 tensin 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CDC42 cell division cycle 42
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
IFITM3 interferon induced transmembrane protein 3
MYOF myoferlin
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SORBS2 sorbin and SH3 domain containing 2
TFPI2 tissue factor pathway inhibitor 2
WFDC2 WAP four-disulfide core domain 2