BRD-A84189516_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A84189516_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ADORA2B adenosine A2b receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASS1 argininosuccinate synthase 1
BLNK B-cell linker
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CCNA1 cyclin A1
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPA3 carboxypeptidase A3 (mast cell)
CSRP1 cysteine and glycine-rich protein 1
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
FAM69A family with sequence similarity 69, member A
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IER5 immediate early response 5
INHBB inhibin, beta B
IPO13 importin 13
KCTD12 potassium channel tetramerization domain containing 12
LIMCH1 LIM and calponin homology domains 1
MEG3 maternally expressed 3 (non-protein coding)
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTSS1 metastasis suppressor 1
NPTX2 neuronal pentraxin II
NVL nuclear VCP-like
OSBPL10 oxysterol binding protein-like 10
P3H2 prolyl 3-hydroxylase 2
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PTX3 pentraxin 3, long
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRGN serglycin
STAR steroidogenic acute regulatory protein
SUSD4 sushi domain containing 4
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AURKB aurora kinase B
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CPNE3 copine III
CRTAP cartilage associated protein
CXCL5 chemokine (C-X-C motif) ligand 5
DCK deoxycytidine kinase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM134B family with sequence similarity 134, member B
FEN1 flap structure-specific endonuclease 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO2 flavin containing monooxygenase 2 (non-functional)
HADH hydroxyacyl-CoA dehydrogenase
HOXC10 homeobox C10
HOXC6 homeobox C6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
LACTB2 lactamase, beta 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSX1 msh homeobox 1
MUC1 mucin 1, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NOTCH2 notch 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
RNASE4 ribonuclease, RNase A family, 4
RPS5 ribosomal protein S5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SORD sorbitol dehydrogenase
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1