BRD-A83124583_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-A83124583_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CBR3 carbonyl reductase 3
CD44 CD44 molecule (Indian blood group)
CDA cytidine deaminase
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GNAS GNAS complex locus
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFA platelet-derived growth factor alpha polypeptide
PIR pirin (iron-binding nuclear protein)
RALB v-ral simian leukemia viral oncogene homolog B
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TRIM16 tripartite motif containing 16
TUBA4A tubulin, alpha 4a
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASCL1 achaete-scute family bHLH transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CFI complement factor I
CHEK2 checkpoint kinase 2
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLUL glutamate-ammonia ligase
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HOXC4 homeobox C4
HOXC6 homeobox C6
IGL immunoglobulin lambda locus
ISOC1 isochorismatase domain containing 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCTP1 multiple C2 domains, transmembrane 1
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NUP107 nucleoporin 107kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFC2 replication factor C (activator 1) 2, 40kDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
TBC1D31 TBC1 domain family, member 31
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
VCAN versican