BRD-A83124583_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-A83124583_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CCND2 cyclin D2
CCNG2 cyclin G2
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLF11 Kruppel-like factor 11
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEG3 maternally expressed 3 (non-protein coding)
MMP1 matrix metallopeptidase 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SH3YL1 SH3 and SYLF domain containing 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS3 suppressor of cytokine signaling 3
TES testin LIM domain protein
TRIB1 tribbles pseudokinase 1
TUFT1 tuftelin 1
UVRAG UV radiation resistance associated
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AREG amphiregulin
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CIRBP cold inducible RNA binding protein
COL6A3 collagen, type VI, alpha 3
COX11 COX11 cytochrome c oxidase copper chaperone
CYC1 cytochrome c-1
DUSP4 dual specificity phosphatase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ENO1 enolase 1, (alpha)
EREG epiregulin
GSTP1 glutathione S-transferase pi 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
IER3 immediate early response 3
KANK1 KN motif and ankyrin repeat domains 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MLEC malectin
PALLD palladin, cytoskeletal associated protein
PBK PDZ binding kinase
PRDX4 peroxiredoxin 4
PYGB phosphorylase, glycogen; brain
RER1 retention in endoplasmic reticulum sorting receptor 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBC1D16 TBC1 domain family, member 16
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM50B transmembrane protein 50B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)