BRD-A82371568_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-A82371568_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AREG amphiregulin
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CPA3 carboxypeptidase A3 (mast cell)
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
EREG epiregulin
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLS glutaminase
GPX2 glutathione peroxidase 2
GUSBP3 glucuronidase, beta pseudogene 3
HEG1 heart development protein with EGF-like domains 1
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MLPH melanophilin
MTCL1 microtubule crosslinking factor 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PRSS23 protease, serine, 23
PSAP prosaposin
PTPRM protein tyrosine phosphatase, receptor type, M
QPCT glutaminyl-peptide cyclotransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOQ ras homolog family member Q
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SFN stratifin
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TCTA T-cell leukemia translocation altered
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52 tumor protein D52
YBX3 Y box binding protein 3
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCK cholecystokinin
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPP4 dipeptidyl-peptidase 4
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM64A family with sequence similarity 64, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GTSE1 G-2 and S-phase expressed 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HSPA1A heat shock 70kDa protein 1A
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMP5 lysosomal-associated membrane protein family, member 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MT1F metallothionein 1F
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OSR2 odd-skipped related transciption factor 2
PBK PDZ binding kinase
PDGFC platelet derived growth factor C
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
QKI QKI, KH domain containing, RNA binding
RAD21 RAD21 homolog (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPTBN1 spectrin, beta, non-erythrocytic 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S