BRD-A81795050_U 18666A_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A81795050_U 18666A_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY1 adenylate cyclase 1 (brain)
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C14ORF1 chromosome 14 open reading frame 1
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA2 chloride channel accessory 2
CLDN3 claudin 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ERLIN2 ER lipid raft associated 2
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM13A family with sequence similarity 13, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FMR1 fragile X mental retardation 1
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GRN granulin
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PGD phosphogluconate dehydrogenase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRR15L proline rich 15-like
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
RAB38 RAB38, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE6 ribonuclease, RNase A family, k6
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAPPC6A trafficking protein particle complex 6A
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
BAG2 BCL2-associated athanogene 2
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC4 chloride intracellular channel 4
CLTB clathrin, light chain B
CRYAB crystallin, alpha B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
EDN1 endothelin 1
EGF epidermal growth factor
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FERMT2 fermitin family member 2
FKBP14 FK506 binding protein 14, 22 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GOLT1B golgi transport 1B
HAS2 hyaluronan synthase 2
IER3 immediate early response 3
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KLF9 Kruppel-like factor 9
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MAP2K3 mitogen-activated protein kinase kinase 3
MFAP3L microfibrillar-associated protein 3-like
MSX1 msh homeobox 1
MT1M metallothionein 1M
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OXTR oxytocin receptor
PLP1 proteolipid protein 1
PMP2 peripheral myelin protein 2
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RDX radixin
RHOBTB3 Rho-related BTB domain containing 3
S100B S100 calcium binding protein B
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRPRB signal recognition particle receptor, B subunit
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNC tenascin C
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1