BRD-A81541225_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-A81541225_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENAH enabled homolog (Drosophila)
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
INHBA inhibin, beta A
INHBE inhibin, beta E
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUP junction plakoglobin
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDE4C phosphodiesterase 4C, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPARG peroxisome proliferator-activated receptor gamma
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PTBP2 polypyrimidine tract binding protein 2
PTHLH parathyroid hormone-like hormone
PXDN peroxidasin
RABGGTB Rab geranylgeranyltransferase, beta subunit
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SHB Src homology 2 domain containing adaptor protein B
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VCAN versican
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CLU clusterin
CTPS1 CTP synthase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM46A family with sequence similarity 46, member A
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNAS GNAS complex locus
GYG1 glycogenin 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXC10 homeobox C10
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
MAOB monoamine oxidase B
MARCKSL1 MARCKS-like 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
OLFM1 olfactomedin 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PRDX4 peroxiredoxin 4
PTDSS1 phosphatidylserine synthase 1
RAP2C RAP2C, member of RAS oncogene family
SCARA3 scavenger receptor class A, member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC46A3 solute carrier family 46, member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SOX2 SRY (sex determining region Y)-box 2
TBC1D4 TBC1 domain family, member 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM9SF2 transmembrane 9 superfamily member 2
TMEM243 transmembrane protein 243, mitochondrial
TPPP3 tubulin polymerization-promoting protein family member 3
TRAM1 translocation associated membrane protein 1
TRD T cell receptor delta locus
TRIL TLR4 interactor with leucine-rich repeats
TYROBP TYRO protein tyrosine kinase binding protein
WFS1 Wolfram syndrome 1 (wolframin)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1