BRD-A81541225_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-A81541225_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
CA12 carbonic anhydrase XII
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CLTB clathrin, light chain B
COL9A3 collagen, type IX, alpha 3
CORO1C coronin, actin binding protein, 1C
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HNRNPL heterogeneous nuclear ribonucleoprotein L
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
RND3 Rho family GTPase 3
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SOX4 SRY (sex determining region Y)-box 4
STC2 stanniocalcin 2
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TLK2 tousled-like kinase 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TRIB1 tribbles pseudokinase 1
TXNRD1 thioredoxin reductase 1
UCK2 uridine-cytidine kinase 2
VNN1 vanin 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANOS1 anosmin 1
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CCNF cyclin F
CIAPIN1 cytokine induced apoptosis inhibitor 1
CKB creatine kinase, brain
CLU clusterin
EDNRA endothelin receptor type A
F13A1 coagulation factor XIII, A1 polypeptide
FAM111A family with sequence similarity 111, member A
GJA1 gap junction protein, alpha 1, 43kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
NAP1L1 nucleosome assembly protein 1-like 1
NDRG3 NDRG family member 3
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PNMA2 paraneoplastic Ma antigen 2
PPIF peptidylprolyl isomerase F
RNASET2 ribonuclease T2
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS3 sorbin and SH3 domain containing 3
SPON1 spondin 1, extracellular matrix protein
TARDBP TAR DNA binding protein
TRIM14 tripartite motif containing 14