BRD-A81541225_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-A81541225_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CD44 CD44 molecule (Indian blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CNN3 calponin 3, acidic
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FPGS folylpolyglutamate synthase
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPL heterogeneous nuclear ribonucleoprotein L
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IL1RL1 interleukin 1 receptor-like 1
INHBA inhibin, beta A
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MME membrane metallo-endopeptidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
AURKA aurora kinase A
CCNF cyclin F
CDC25A cell division cycle 25A
COL4A6 collagen, type IV, alpha 6
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGLN3 egl-9 family hypoxia-inducible factor 3
FASTKD5 FAST kinase domains 5
FCGBP Fc fragment of IgG binding protein
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LYPD1 LY6/PLAUR domain containing 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
NSG1 neuron specific gene family member 1
OLFM1 olfactomedin 1
PBX1 pre-B-cell leukemia homeobox 1
PI3 peptidase inhibitor 3, skin-derived
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SATB2 SATB homeobox 2
SLPI secretory leukocyte peptidase inhibitor
VWA5A von Willebrand factor A domain containing 5A