BRD-A80502530_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-A80502530_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
AMOTL2 angiomotin like 2
ANXA3 annexin A3
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CCNL1 cyclin L1
CDCA4 cell division cycle associated 4
CDK17 cyclin-dependent kinase 17
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CORO1C coronin, actin binding protein, 1C
CREM cAMP responsive element modulator
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DOCK4 dedicator of cytokinesis 4
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNA1 ephrin-A1
EGR1 early growth response 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FAM60A family with sequence similarity 60, member A
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HSPA13 heat shock protein 70kDa family, member 13
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
INHBA inhibin, beta A
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
LAMP3 lysosomal-associated membrane protein 3
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MEIS2 Meis homeobox 2
NCOA2 nuclear receptor coactivator 2
NF1 neurofibromin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NUPL1 nucleoporin like 1
NXN nucleoredoxin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PTBP2 polypyrimidine tract binding protein 2
PTRF polymerase I and transcript release factor
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RIT1 Ras-like without CAAX 1
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SC5D sterol-C5-desaturase
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
STK17A serine/threonine kinase 17a
STOM stomatin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BPIFA1 BPI fold containing family A, member 1
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLCA1 chloride channel accessory 1
CLU clusterin
COG2 component of oligomeric golgi complex 2
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DGKZ diacylglycerol kinase, zeta
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
EIF5A eukaryotic translation initiation factor 5A
FANCF Fanconi anemia, complementation group F
FBXO9 F-box protein 9
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGLJ3 immunoglobulin lambda joining 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INTS3 integrator complex subunit 3
KCTD12 potassium channel tetramerization domain containing 12
LARS leucyl-tRNA synthetase
LINC00341 long intergenic non-protein coding RNA 341
MAT2A methionine adenosyltransferase II, alpha
METTL13 methyltransferase like 13
NMRK1 nicotinamide riboside kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAD51C RAD51 paralog C
RPP40 ribonuclease P/MRP 40kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SETD6 SET domain containing 6
SIRT5 sirtuin 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPDEF SAM pointed domain containing ETS transcription factor
SRGN serglycin
STAMBP STAM binding protein
STEAP3 STEAP family member 3, metalloreductase
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOX3 TOX high mobility group box family member 3
TRAK2 trafficking protein, kinesin binding 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN31 tetraspanin 31
TXNDC9 thioredoxin domain containing 9
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZNF185 zinc finger protein 185 (LIM domain)
ZNF302 zinc finger protein 302
ZNF573 zinc finger protein 573