BRD-A80502530_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

418 genes differentially expressed following the BRD-A80502530_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
AKIRIN1 akirin 1
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CENPE centromere protein E, 312kDa
CLEC2B C-type lectin domain family 2, member B
CLK4 CDC-like kinase 4
CLSTN1 calsyntenin 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CREM cAMP responsive element modulator
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
DCP1A decapping mRNA 1A
DDIT3 DNA-damage-inducible transcript 3
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGR1 early growth response 1
EIF1B eukaryotic translation initiation factor 1B
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FBXO11 F-box protein 11
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GLS glutaminase
GPATCH8 G patch domain containing 8
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HOPX HOP homeobox
HOXA1 homeobox A1
HSPA13 heat shock protein 70kDa family, member 13
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL7R interleukin 7 receptor
INSR insulin receptor
IST1 increased sodium tolerance 1 homolog (yeast)
KAT6A K(lysine) acetyltransferase 6A
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0907 KIAA0907
KLF10 Kruppel-like factor 10
KLHL24 kelch-like family member 24
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MKRN1 makorin ring finger protein 1
MT1E metallothionein 1E
MTCH1 mitochondrial carrier 1
MTF2 metal response element binding transcription factor 2
NDEL1 nudE neurodevelopment protein 1-like 1
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NRIP3 nuclear receptor interacting protein 3
NUPL1 nucleoporin like 1
OSER1 oxidative stress responsive serine-rich 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PKN2 protein kinase N2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNISR PNN-interacting serine/arginine-rich protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTTG1 pituitary tumor-transforming 1
PUM1 pumilio RNA-binding family member 1
RAB8B RAB8B, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RBM25 RNA binding motif protein 25
RBM5 RNA binding motif protein 5
RBP4 retinol binding protein 4, plasma
RCOR1 REST corepressor 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RNF11 ring finger protein 11
RNMT RNA (guanine-7-) methyltransferase
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RSRP1 arginine/serine-rich protein 1
RYBP RING1 and YY1 binding protein
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SDC2 syndecan 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEC24A SEC24 family member A
SENP6 SUMO1/sentrin specific peptidase 6
SERINC1 serine incorporator 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC35F5 solute carrier family 35, member F5
SMNDC1 survival motor neuron domain containing 1
SPAG9 sperm associated antigen 9
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAC1 tachykinin, precursor 1
TANK TRAF family member-associated NFKB activator
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TMEM41B transmembrane protein 41B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRA2A transformer 2 alpha homolog (Drosophila)
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBAP1 ubiquitin associated protein 1
UBXN7 UBX domain protein 7
UFM1 ubiquitin-fold modifier 1
USP34 ubiquitin specific peptidase 34
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR47 WD repeat domain 47
WSB1 WD repeat and SOCS box containing 1
YTHDC1 YTH domain containing 1
ZMYM2 zinc finger, MYM-type 2
ZMYM5 zinc finger, MYM-type 5
ZNF292 zinc finger protein 292
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACAT1 acetyl-CoA acetyltransferase 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADSL adenylosuccinate lyase
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA4 annexin A4
ANXA9 annexin A9
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP1 Rho GTPase activating protein 1
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASB13 ankyrin repeat and SOCS box containing 13
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATMIN ATM interactor
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
C17ORF62 chromosome 17 open reading frame 62
C21ORF33 chromosome 21 open reading frame 33
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CARD10 caspase recruitment domain family, member 10
CBS cystathionine-beta-synthase
CCDC53 coiled-coil domain containing 53
CDK4 cyclin-dependent kinase 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETN3 centrin, EF-hand protein, 3
CHMP7 charged multivesicular body protein 7
CKAP4 cytoskeleton-associated protein 4
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COA3 cytochrome c oxidase assembly factor 3
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CPNE3 copine III
CRISP3 cysteine-rich secretory protein 3
CSK c-src tyrosine kinase
CTBP1 C-terminal binding protein 1
CTSL cathepsin L
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DCPS decapping enzyme, scavenger
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DES desmin
DIXDC1 DIX domain containing 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL2 dihydropyrimidinase-like 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
FANCF Fanconi anemia, complementation group F
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FH fumarate hydratase
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD2 FXYD domain containing ion transport regulator 2
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLOD4 glyoxalase domain containing 4
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX2 glutathione peroxidase 2
GTF3A general transcription factor IIIA
GYG1 glycogenin 1
HADH hydroxyacyl-CoA dehydrogenase
HSPA8 heat shock 70kDa protein 8
ICAM3 intercellular adhesion molecule 3
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP1 insulin-like growth factor binding protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRAK1 interleukin-1 receptor-associated kinase 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KRT19 keratin 19, type I
LAMA5 laminin, alpha 5
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIPA lipase A, lysosomal acid, cholesterol esterase
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAGEF1 melanoma antigen family F1
MANSC1 MANSC domain containing 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MB myoglobin
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MINA MYC induced nuclear antigen
MLPH melanophilin
MOCS2 molybdenum cofactor synthesis 2
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MRPL24 mitochondrial ribosomal protein L24
MRPL3 mitochondrial ribosomal protein L3
MRPS16 mitochondrial ribosomal protein S16
MRPS33 mitochondrial ribosomal protein S33
MSMB microseminoprotein, beta-
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NBN nibrin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NMI N-myc (and STAT) interactor
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPEPL1 aminopeptidase-like 1
NRCAM neuronal cell adhesion molecule
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NT5E 5'-nucleotidase, ecto (CD73)
NTHL1 nth endonuclease III-like 1 (E. coli)
NUP37 nucleoporin 37kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OXLD1 oxidoreductase-like domain containing 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCYOX1L prenylcysteine oxidase 1 like
PDS5A PDS5 cohesin associated factor A
PDZK1 PDZ domain containing 1
PDZRN3 PDZ domain containing ring finger 3
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
PLAT plasminogen activator, tissue
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPA2 pyrophosphatase (inorganic) 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
PWP1 PWP1 homolog (S. cerevisiae)
PYGL phosphorylase, glycogen, liver
R3HDM2 R3H domain containing 2
RAB31 RAB31, member RAS oncogene family
RAD51C RAD51 paralog C
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASEH2A ribonuclease H2, subunit A
RNASET2 ribonuclease T2
RNF187 ring finger protein 187
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100A14 S100 calcium binding protein A14
SAMM50 SAMM50 sorting and assembly machinery component
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC25A46 solute carrier family 25, member 46
SLC2A4RG SLC2A4 regulator
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORD sorbitol dehydrogenase
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
STAMBP STAM binding protein
STC1 stanniocalcin 1
STEAP3 STEAP family member 3, metalloreductase
STRA13 stimulated by retinoic acid 13
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SVIL supervillin
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THYN1 thymocyte nuclear protein 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM5 transmembrane protein 5
TNNC1 troponin C type 1 (slow)
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRAPPC12 trafficking protein particle complex 12
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBL4A ubiquitin-like 4A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UNG uracil-DNA glycosylase
URI1 URI1, prefoldin-like chaperone
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZIC1 Zic family member 1
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein