BRD-A80502530_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A80502530_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
AREG amphiregulin
ARG1 arginase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF3 activating transcription factor 3
BCHE butyrylcholinesterase
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCDC88A coiled-coil domain containing 88A
CCNL1 cyclin L1
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK6 cyclin-dependent kinase 6
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
EAF2 ELL associated factor 2
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
INHBA inhibin, beta A
INHBB inhibin, beta B
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT8 keratin 8, type II
LAMP5 lysosomal-associated membrane protein family, member 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP9 matrix metallopeptidase 9
MSRA methionine sulfoxide reductase A
MXRA5 matrix-remodelling associated 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTBP2 polypyrimidine tract binding protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RPL10 ribosomal protein L10
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFRC transferrin receptor
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TNS1 tensin 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZNF430 zinc finger protein 430

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
C14ORF169 chromosome 14 open reading frame 169
C14ORF2 chromosome 14 open reading frame 2
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAST calpastatin
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CD163 CD163 molecule
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EXT1 exostosin glycosyltransferase 1
FAM134B family with sequence similarity 134, member B
GSAP gamma-secretase activating protein
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KCTD12 potassium channel tetramerization domain containing 12
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MCAM melanoma cell adhesion molecule
MCOLN1 mucolipin 1
NDRG2 NDRG family member 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
PF4 platelet factor 4
PLA2G16 phospholipase A2, group XVI
PLBD1 phospholipase B domain containing 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRR7 proline rich 7 (synaptic)
PWP1 PWP1 homolog (S. cerevisiae)
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SPATA20 spermatogenesis associated 20
SPRR3 small proline-rich protein 3
TBCB tubulin folding cofactor B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THAP11 THAP domain containing 11
TPD52L1 tumor protein D52-like 1
TRIP6 thyroid hormone receptor interactor 6
WBP5 WW domain binding protein 5
WNT5A wingless-type MMTV integration site family, member 5A
ZC3H4 zinc finger CCCH-type containing 4