BRD-A79768653_sirolimus_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

136 genes differentially expressed following the BRD-A79768653_sirolimus_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AHNAK2 AHNAK nucleoprotein 2
BASP1 brain abundant, membrane attached signal protein 1
BZW2 basic leucine zipper and W2 domains 2
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
CREB1 cAMP responsive element binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
DPP4 dipeptidyl-peptidase 4
FAS Fas cell surface death receptor
GDF15 growth differentiation factor 15
GRN granulin
HBB hemoglobin, beta
HBD hemoglobin, delta
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HOOK2 hook microtubule-tethering protein 2
HOPX HOP homeobox
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB5 integrin, beta 5
KLHDC2 kelch domain containing 2
KLHL9 kelch-like family member 9
LXN latexin
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MVP major vault protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDRG1 N-myc downstream regulated 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAU plasminogen activator, urokinase
PYGL phosphorylase, glycogen, liver
QARS glutaminyl-tRNA synthetase
REEP5 receptor accessory protein 5
REG3A regenerating islet-derived 3 alpha
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
SESN1 sestrin 1
SLC16A6 solute carrier family 16, member 6
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPP1 secreted phosphoprotein 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGIF1 TGFB-induced factor homeobox 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFP alpha-fetoprotein
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOE apolipoprotein E
BEX1 brain expressed, X-linked 1
C3 complement component 3
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD58 CD58 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC27 cell division cycle 27
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRABP1 cellular retinoic acid binding protein 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
ETNK1 ethanolamine kinase 1
EXOSC4 exosome component 4
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP11 glucuronidase, beta pseudogene 11
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXA5 homeobox A5
HOXB2 homeobox B2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL1R2 interleukin 1 receptor, type II
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KRT15 keratin 15, type I
LY6E lymphocyte antigen 6 complex, locus E
MAOA monoamine oxidase A
MFN2 mitofusin 2
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ORM1 orosomucoid 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PRKCB protein kinase C, beta
PRKCQ protein kinase C, theta
PRNP prion protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SRSF2 serine/arginine-rich splicing factor 2
TIMP3 TIMP metallopeptidase inhibitor 3
UBE2S ubiquitin-conjugating enzyme E2S
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28