BRD-A79768653_sirolimus_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A79768653_sirolimus_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMOTL2 angiomotin like 2
CALCOCO1 calcium binding and coiled-coil domain 1
CCND1 cyclin D1
CD200 CD200 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLIC5 chloride intracellular channel 5
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CTSH cathepsin H
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEPTOR DEP domain containing MTOR-interacting protein
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK9 dedicator of cytokinesis 9
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
H2AFY H2A histone family, member Y
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGA2 high mobility group AT-hook 2
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
LOC100272216 uncharacterized LOC100272216
MAGED1 melanoma antigen family D1
MAN1C1 mannosidase, alpha, class 1C, member 1
METRN meteorin, glial cell differentiation regulator
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G16 phospholipase A2, group XVI
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBKS ribokinase
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGL1 ral guanine nucleotide dissociation stimulator-like 1
SH3YL1 SH3 and SYLF domain containing 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSBP2 single-stranded DNA binding protein 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRAPPC6A trafficking protein particle complex 6A
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALDOC aldolase C, fructose-bisphosphate
AQP9 aquaporin 9
ASCL1 achaete-scute family bHLH transcription factor 1
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CHN1 chimerin 1
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
FADS1 fatty acid desaturase 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
HBB hemoglobin, beta
HSPA14 heat shock 70kDa protein 14
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NRIP3 nuclear receptor interacting protein 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBK PDZ binding kinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
RGS2 regulator of G-protein signaling 2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SPRR1A small proline-rich protein 1A
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2