BRD-A79768653_sirolimus_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-A79768653_sirolimus_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD5 C2 calcium-dependent domain containing 5
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CD24 CD24 molecule
EFNA1 ephrin-A1
EVL Enah/Vasp-like
FGG fibrinogen gamma chain
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MXI1 MAX interactor 1, dimerization protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC1 syndecan 1
SH3BGRL SH3 domain binding glutamate-rich protein like
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
C3 complement component 3
CXCL2 chemokine (C-X-C motif) ligand 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
HAL histidine ammonia-lyase
HSPB8 heat shock 22kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
LAPTM4B lysosomal protein transmembrane 4 beta
LMO4 LIM domain only 4
MT1E metallothionein 1E
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
PGC progastricsin (pepsinogen C)
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SQLE squalene epoxidase