BRD-A79768653_sirolimus_LNCAP_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-A79768653_sirolimus_LNCAP_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADIRF adipogenesis regulatory factor
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BASP1 brain abundant, membrane attached signal protein 1
BCL2L1 BCL2-like 1
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HBB hemoglobin, beta
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
KIAA1033 KIAA1033
KLK2 kallikrein-related peptidase 2
LAMA5 laminin, alpha 5
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAMLD1 mastermind-like domain containing 1
MDK midkine (neurite growth-promoting factor 2)
MSMB microseminoprotein, beta-
MYO5C myosin VC
NKX3-1 NK3 homeobox 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PENK proenkephalin
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGES prostaglandin E synthase
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS2 regulator of G-protein signaling 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SMAD3 SMAD family member 3
SNAP23 synaptosomal-associated protein, 23kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SRGN serglycin
TNS1 tensin 1
TSPAN6 tetraspanin 6
TSPYL5 TSPY-like 5
UPK1B uroplakin 1B
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25B cell division cycle 25B
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
E2F2 E2F transcription factor 2
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GARS glycyl-tRNA synthetase
IGHM immunoglobulin heavy constant mu
JUN jun proto-oncogene
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAM1 neural cell adhesion molecule 1
NUP85 nucleoporin 85kDa
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase