BRD-A79768653_sirolimus_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A79768653_sirolimus_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
ASPN asporin
ASS1 argininosuccinate synthase 1
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CD14 CD14 molecule
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSH cathepsin H
DCN decorin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H2AC histone cluster 1, H2ac
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF2 Kruppel-like factor 2
KLF7 Kruppel-like factor 7 (ubiquitous)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LEPR leptin receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MTSS1 metastasis suppressor 1
NCF2 neutrophil cytosolic factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PER1 period circadian clock 1
PROM1 prominin 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STK38L serine/threonine kinase 38 like
SYT1 synaptotagmin I
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TREM1 triggering receptor expressed on myeloid cells 1
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
VCAN versican
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
COL1A2 collagen, type I, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ERAP2 endoplasmic reticulum aminopeptidase 2
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HK2 hexokinase 2
IFRD2 interferon-related developmental regulator 2
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
MAP7 microtubule-associated protein 7
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NET1 neuroepithelial cell transforming 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PNP purine nucleoside phosphorylase
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
SHCBP1 SHC SH2-domain binding protein 1
SRSF6 serine/arginine-rich splicing factor 6
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMELESS timeless circadian clock
TMEM97 transmembrane protein 97
TNC tenascin C
TOMM34 translocase of outer mitochondrial membrane 34
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
ZWINT ZW10 interacting kinetochore protein