BRD-A79768653_sirolimus_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-A79768653_sirolimus_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP2 amyloid beta (A4) precursor-like protein 2
CADM1 cell adhesion molecule 1
CCDC90B coiled-coil domain containing 90B
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
DFNA5 deafness, autosomal dominant 5
HIST1H2AC histone cluster 1, H2ac
HIST1H4C histone cluster 1, H4c
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
PLIN2 perilipin 2
POSTN periostin, osteoblast specific factor
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TGIF1 TGFB-induced factor homeobox 1
TMEM135 transmembrane protein 135
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
C1ORF116 chromosome 1 open reading frame 116
C1R complement component 1, r subcomponent
CRISP3 cysteine-rich secretory protein 3
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BG histone cluster 1, H2bg
HOXA10 homeobox A10
IGKC immunoglobulin kappa constant
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MSLN mesothelin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RHCG Rh family, C glycoprotein
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR3 small proline-rich protein 3
TFF3 trefoil factor 3 (intestinal)