BRD-A79768653_sirolimus_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-A79768653_sirolimus_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
CA2 carbonic anhydrase II
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP2A charged multivesicular body protein 2A
COL8A2 collagen, type VIII, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSE dermatan sulfate epimerase
DSP desmoplakin
DST dystonin
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP11 FK506 binding protein 11, 19 kDa
FST follistatin
G0S2 G0/G1 switch 2
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GRN granulin
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
LOXL2 lysyl oxidase-like 2
MAP1B microtubule-associated protein 1B
MDFIC MyoD family inhibitor domain containing
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSAP prosaposin
PTHLH parathyroid hormone-like hormone
QPCT glutaminyl-peptide cyclotransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNC tenascin C
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AUTS2 autism susceptibility candidate 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD320 CD320 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFI complement factor I
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
FOLR1 folate receptor 1 (adult)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
H2BFS H2B histone family, member S (pseudogene)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INSIG1 insulin induced gene 1
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
LRIF1 ligand dependent nuclear receptor interacting factor 1
MALL mal, T-cell differentiation protein-like
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC16 mucin 16, cell surface associated
NCALD neurocalcin delta
ODC1 ornithine decarboxylase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PON2 paraoxonase 2
PRSS2 protease, serine, 2 (trypsin 2)
PRUNE2 prune homolog 2 (Drosophila)
RGS2 regulator of G-protein signaling 2
S100A9 S100 calcium binding protein A9
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SRGN serglycin
SYBU syntabulin (syntaxin-interacting)
TSPAN12 tetraspanin 12
TSPYL5 TSPY-like 5
WT1 Wilms tumor 1