BRD-A79768653_sirolimus_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A79768653_sirolimus_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
APOD apolipoprotein D
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND1 cyclin D1
CD9 CD9 molecule
CLDN10 claudin 10
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSB cathepsin B
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
FZD6 frizzled class receptor 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPR137B G protein-coupled receptor 137B
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL1B interleukin 1, beta
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KLF2 Kruppel-like factor 2
KLK11 kallikrein-related peptidase 11
LAMA3 laminin, alpha 3
LTBP2 latent transforming growth factor beta binding protein 2
METRN meteorin, glial cell differentiation regulator
MME membrane metallo-endopeptidase
NAGK N-acetylglucosamine kinase
NAP1L1 nucleosome assembly protein 1-like 1
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PERP PERP, TP53 apoptosis effector
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDC1 PX domain containing 1
QPCT glutaminyl-peptide cyclotransferase
RAB40B RAB40B, member RAS oncogene family
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TUBB6 tubulin, beta 6 class V
UPK1B uroplakin 1B
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
BEX1 brain expressed, X-linked 1
C1QA complement component 1, q subcomponent, A chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
GLUL glutamate-ammonia ligase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
LAPTM4B lysosomal protein transmembrane 4 beta
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
PLAC8 placenta-specific 8
PTP4A3 protein tyrosine phosphatase type IVA, member 3
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAP25 synaptosomal-associated protein, 25kDa
TIMP3 TIMP metallopeptidase inhibitor 3