BRD-A79768653_sirolimus_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A79768653_sirolimus_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASMTL acetylserotonin O-methyltransferase-like
ATF4 activating transcription factor 4
BCL6 B-cell CLL/lymphoma 6
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CCDC28A coiled-coil domain containing 28A
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CEP68 centrosomal protein 68kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
EIF4B eukaryotic translation initiation factor 4B
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
HACD1 3-hydroxyacyl-CoA dehydratase 1
KLF6 Kruppel-like factor 6
LETMD1 LETM1 domain containing 1
MXRA7 matrix-remodelling associated 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFD platelet derived growth factor D
RBKS ribokinase
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERINC3 serine incorporator 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM230 transmembrane protein 230
TP53I3 tumor protein p53 inducible protein 3
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
WNK1 WNK lysine deficient protein kinase 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C4BPA complement component 4 binding protein, alpha
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDA cytidine deaminase
CDC25A cell division cycle 25A
CSTA cystatin A (stefin A)
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GPER1 G protein-coupled estrogen receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
LTF lactotransferrin
MMP12 matrix metallopeptidase 12
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYLK myosin light chain kinase
NES nestin
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCAN1 regulator of calcineurin 1
RCAN2 regulator of calcineurin 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPP1 secreted phosphoprotein 1
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNC tenascin C
TPD52 tumor protein D52
TSPAN8 tetraspanin 8
USP6NL USP6 N-terminal like