BRD-A79768653_sirolimus_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-A79768653_sirolimus_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMOTL2 angiomotin like 2
AQP1 aquaporin 1 (Colton blood group)
ATP8B4 ATPase, class I, type 8B, member 4
CCL2 chemokine (C-C motif) ligand 2
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DCN decorin
DSP desmoplakin
EDN1 endothelin 1
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GAS1 growth arrest-specific 1
INHBA inhibin, beta A
MMP12 matrix metallopeptidase 12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH3 notch 3
NREP neuronal regeneration related protein
PDLIM5 PDZ and LIM domain 5
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PRR16 proline rich 16
QPCT glutaminyl-peptide cyclotransferase
RAD23A RAD23 homolog A (S. cerevisiae)
SCYL3 SCY1-like 3 (S. cerevisiae)
SULF1 sulfatase 1
TOR1A torsin family 1, member A (torsin A)
TYROBP TYRO protein tyrosine kinase binding protein

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CD44 CD44 molecule (Indian blood group)
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELOVL5 ELOVL fatty acid elongase 5
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
GLIPR1 GLI pathogenesis-related 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
LRP4 low density lipoprotein receptor-related protein 4
METTL7A methyltransferase like 7A
MSLN mesothelin
NFIL3 nuclear factor, interleukin 3 regulated
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
OPHN1 oligophrenin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAX8 paired box 8
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAC8 placenta-specific 8
RBP1 retinol binding protein 1, cellular
RNASET2 ribonuclease T2
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPAG4 sperm associated antigen 4
SPON1 spondin 1, extracellular matrix protein
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TFRC transferrin receptor
USP6NL USP6 N-terminal like