BRD-A79768653_sirolimus_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-A79768653_sirolimus_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AZU1 azurocidin 1
BEX1 brain expressed, X-linked 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN18 claudin 18
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTBP1 C-terminal binding protein 1
EDN1 endothelin 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN5 fibulin 5
FBN2 fibrillin 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GRN granulin
H1FX H1 histone family, member X
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER5 immediate early response 5
ITGA6 integrin, alpha 6
KIAA0355 KIAA0355
KLF6 Kruppel-like factor 6
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PTX3 pentraxin 3, long
PXDN peroxidasin
RAB4A RAB4A, member RAS oncogene family
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SULF1 sulfatase 1
TM4SF1 transmembrane 4 L six family member 1
TSPAN5 tetraspanin 5
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG1 adhesion G protein-coupled receptor G1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CFH complement factor H
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CTH cystathionine gamma-lyase
CTSC cathepsin C
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF4B eukaryotic translation initiation factor 4B
ENO1 enolase 1, (alpha)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
OAT ornithine aminotransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAX8 paired box 8
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
QPRT quinolinate phosphoribosyltransferase
RBM47 RNA binding motif protein 47
SAP30 Sin3A-associated protein, 30kDa
SCARB1 scavenger receptor class B, member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
THAP11 THAP domain containing 11
TLR4 toll-like receptor 4
TNC tenascin C
TPI1 triosephosphate isomerase 1
VEGFA vascular endothelial growth factor A