BRD-A79768653_sirolimus_H1299_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

137 genes differentially expressed following the BRD-A79768653_sirolimus_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AEBP1 AE binding protein 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK6 cyclin-dependent kinase 6
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EVI2B ecotropic viral integration site 2B
F13A1 coagulation factor XIII, A1 polypeptide
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KLK10 kallikrein-related peptidase 10
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LTBP1 latent transforming growth factor beta binding protein 1
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORC1 origin recognition complex, subunit 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSAT1 phosphoserine aminotransferase 1
PYCARD PYD and CARD domain containing
RGS4 regulator of G-protein signaling 4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SARS seryl-tRNA synthetase
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORD sorbitol dehydrogenase
SULF1 sulfatase 1
TRIB3 tribbles pseudokinase 3
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
WDTC1 WD and tetratricopeptide repeats 1
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BAD BCL2-associated agonist of cell death
CA2 carbonic anhydrase II
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CLU clusterin
CPNE3 copine III
EIF5B eukaryotic translation initiation factor 5B
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GRAMD3 GRAM domain containing 3
HCP5 HLA complex P5 (non-protein coding)
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
IFITM3 interferon induced transmembrane protein 3
IGHM immunoglobulin heavy constant mu
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
MAP7 microtubule-associated protein 7
MRPL15 mitochondrial ribosomal protein L15
MRPS28 mitochondrial ribosomal protein S28
MSH6 mutS homolog 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NT5DC2 5'-nucleotidase domain containing 2
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PLCB4 phospholipase C, beta 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SNRPG small nuclear ribonucleoprotein polypeptide G
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TSC22D2 TSC22 domain family, member 2
TXNDC9 thioredoxin domain containing 9