BRD-A79768653_sirolimus_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-A79768653_sirolimus_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
CAST calpastatin
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CP ceruloplasmin (ferroxidase)
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CYBRD1 cytochrome b reductase 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
F13A1 coagulation factor XIII, A1 polypeptide
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLPH3L golgi phosphoprotein 3-like
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
GRN granulin
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IL6ST interleukin 6 signal transducer
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JADE2 jade family PHD finger 2
JUND jun D proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KIAA1598
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS9 lectin, galactoside-binding, soluble, 9
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MYB v-myb avian myeloblastosis viral oncogene homolog
NDRG2 NDRG family member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PCM1 pericentriolar material 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PLAGL1 pleiomorphic adenoma gene-like 1
PLSCR4 phospholipid scramblase 4
RAB13 RAB13, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RNASE4 ribonuclease, RNase A family, 4
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
TNS3 tensin 3
TRAPPC6A trafficking protein particle complex 6A
TUBA1A tubulin, alpha 1a
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
YPEL5 yippee-like 5 (Drosophila)
ZFHX4 zinc finger homeobox 4

decreased expression

Symbol Name
ACO1 aconitase 1, soluble
ACTG2 actin, gamma 2, smooth muscle, enteric
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
BZW2 basic leucine zipper and W2 domains 2
CCDC86 coiled-coil domain containing 86
CTSE cathepsin E
CXCL9 chemokine (C-X-C motif) ligand 9
EFNB2 ephrin-B2
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM57A family with sequence similarity 57, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
G0S2 G0/G1 switch 2
GGCT gamma-glutamylcyclotransferase
GLRX3 glutaredoxin 3
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP4 GTP binding protein 4
HOMER1 homer scaffolding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL2RG interleukin 2 receptor, gamma
IPO5 importin 5
ITM2A integral membrane protein 2A
LAMB3 laminin, beta 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MORC4 MORC family CW-type zinc finger 4
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
ODC1 ornithine decarboxylase 1
PCP4 Purkinje cell protein 4
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
QPCT glutaminyl-peptide cyclotransferase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMD4A sterile alpha motif domain containing 4A
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
STOML2 stomatin (EPB72)-like 2
TESC tescalcin
TGFA transforming growth factor, alpha
TMEM126B transmembrane protein 126B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMX2 thioredoxin-related transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)