BRD-A79768653_sirolimus_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A79768653_sirolimus_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYD dihydropyrimidine dehydrogenase
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
FBN1 fibrillin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FZD6 frizzled class receptor 6
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GOLGA8H golgin A8 family, member H
H1FX H1 histone family, member X
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IVNS1ABP influenza virus NS1A binding protein
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LGALS8 lectin, galactoside-binding, soluble, 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MSN moesin
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NPTX2 neuronal pentraxin II
PDGFD platelet derived growth factor D
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3BGRL SH3 domain binding glutamate-rich protein like
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
VCAN versican
WBP5 WW domain binding protein 5
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
CALML4 calmodulin-like 4
CCDC86 coiled-coil domain containing 86
CDKN2A cyclin-dependent kinase inhibitor 2A
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CTSZ cathepsin Z
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHRS2 dehydrogenase/reductase (SDR family) member 2
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IGHM immunoglobulin heavy constant mu
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF20A kinesin family member 20A
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
PAX5 paired box 5
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS11 ribosomal protein S11
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
TBX3 T-box 3
TOB1 transducer of ERBB2, 1