BRD-A79768653_sirolimus_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-A79768653_sirolimus_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
BEX4 brain expressed, X-linked 4
C14ORF159 chromosome 14 open reading frame 159
CADPS2 Ca++-dependent secretion activator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCR7 chemokine (C-C motif) receptor 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
DDAH1 dimethylarginine dimethylaminohydrolase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
EPS8 epidermal growth factor receptor pathway substrate 8
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTPRK protein tyrosine phosphatase, receptor type, K
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX11 SRY (sex determining region Y)-box 11
STAT1 signal transducer and activator of transcription 1, 91kDa
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIB2 tribbles pseudokinase 2
TSPAN4 tetraspanin 4
TST thiosulfate sulfurtransferase (rhodanese)
VCAN versican

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BMPR1A bone morphogenetic protein receptor, type IA
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHEK2 checkpoint kinase 2
CLU clusterin
CYB5A cytochrome b5 type A (microsomal)
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSPA2 heat shock 70kDa protein 2
MCM10 minichromosome maintenance complex component 10
MMP9 matrix metallopeptidase 9
NLRP2 NLR family, pyrin domain containing 2
NRIP3 nuclear receptor interacting protein 3
NUSAP1 nucleolar and spindle associated protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTCH1 patched 1
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPARCL1 SPARC-like 1 (hevin)
TUBB tubulin, beta class I
USP6NL USP6 N-terminal like