BRD-A76941896_Doxorubicin hydrochloride_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A76941896_Doxorubicin hydrochloride_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BACE2 beta-site APP-cleaving enzyme 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BSG basigin (Ok blood group)
CLC Charcot-Leyden crystal galectin
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
EPYC epiphycan
EXPH5 exophilin 5
FBN2 fibrillin 2
FPR3 formyl peptide receptor 3
HAUS2 HAUS augmin-like complex, subunit 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INA internexin neuronal intermediate filament protein, alpha
LAMP3 lysosomal-associated membrane protein 3
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5DC2 5'-nucleotidase domain containing 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4C phosphodiesterase 4C, cAMP-specific
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
RNF167 ring finger protein 167
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SYBU syntabulin (syntaxin-interacting)
TPD52 tumor protein D52
USP34 ubiquitin specific peptidase 34

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AREG amphiregulin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CHMP7 charged multivesicular body protein 7
CNN1 calponin 1, basic, smooth muscle
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GSPT2 G1 to S phase transition 2
HBEGF heparin-binding EGF-like growth factor
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KRT14 keratin 14, type I
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MED28 mediator complex subunit 28
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NXT1 nuclear transport factor 2-like export factor 1
PANK2 pantothenate kinase 2
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PNMA1 paraneoplastic Ma antigen 1
PRPF4B pre-mRNA processing factor 4B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAB22A RAB22A, member RAS oncogene family
RIPK4 receptor-interacting serine-threonine kinase 4
SEC24B SEC24 family member B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
STC2 stanniocalcin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TFAM transcription factor A, mitochondrial
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSNAX translin-associated factor X
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZDHHC7 zinc finger, DHHC-type containing 7
ZMYM2 zinc finger, MYM-type 2