BRD-A76528577_Vincristine sulfate_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A76528577_Vincristine sulfate_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
BHLHE41 basic helix-loop-helix family, member e41
CAB39 calcium binding protein 39
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD14 CD14 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNPY3 canopy FGF signaling regulator 3
CPM carboxypeptidase M
CST1 cystatin SN
CYFIP1 cytoplasmic FMR1 interacting protein 1
DMD dystrophin
DMXL2 Dmx-like 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
EFNB2 ephrin-B2
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
FXYD3 FXYD domain containing ion transport regulator 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
IPO13 importin 13
ITGA6 integrin, alpha 6
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
LPAR1 lysophosphatidic acid receptor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPY1R neuropeptide Y receptor Y1
PEX11A peroxisomal biogenesis factor 11 alpha
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB9A RAB9A, member RAS oncogene family
S100A11 S100 calcium binding protein A11
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG1 sperm associated antigen 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSFA2 sperm specific antigen 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STS steroid sulfatase (microsomal), isozyme S
STX1A syntaxin 1A (brain)
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TTLL7 tubulin tyrosine ligase-like family member 7
UNC13B unc-13 homolog B (C. elegans)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOB apolipoprotein B
ASPN asporin
BCL2L1 BCL2-like 1
BID BH3 interacting domain death agonist
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CD200 CD200 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK1 cyclin-dependent kinase 1
CHMP4A charged multivesicular body protein 4A
CLNS1A chloride channel, nucleotide-sensitive, 1A
CLU clusterin
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DICER1 dicer 1, ribonuclease type III
E2F2 E2F transcription factor 2
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
GCH1 GTP cyclohydrolase 1
GPX3 glutathione peroxidase 3
GSTT1 glutathione S-transferase theta 1
HP haptoglobin
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LRRC16A leucine rich repeat containing 16A
LRRC17 leucine rich repeat containing 17
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
ORM1 orosomucoid 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PRDX2 peroxiredoxin 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RPS11 ribosomal protein S11
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC38A1 solute carrier family 38, member 1
SMAD1 SMAD family member 1
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TRAK2 trafficking protein, kinesin binding 2
TTPAL tocopherol (alpha) transfer protein-like
TTR transthyretin
TYMS thymidylate synthetase
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF24 zinc finger protein 24