BRD-A75931230_7706-0139_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A75931230_7706-0139_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AOX1 aldehyde oxidase 1
AREG amphiregulin
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPE carboxypeptidase E
CTSZ cathepsin Z
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPAS1 endothelial PAS domain protein 1
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAP7 microtubule-associated protein 7
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM1 PDZ and LIM domain 1
PKP2 plakophilin 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS10 regulator of G-protein signaling 10
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT1 serine peptidase inhibitor, Kunitz type 1
STON1 stonin 1
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TRIM22 tripartite motif containing 22
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBX5 chromobox homolog 5
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPN centromere protein N
CHL1 cell adhesion molecule L1-like
CKS1B CDC28 protein kinase regulatory subunit 1B
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB1 high mobility group box 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLHL21 kelch-like family member 21
KRT10 keratin 10, type I
LBR lamin B receptor
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NCAPG2 non-SMC condensin II complex, subunit G2
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
NT5DC2 5'-nucleotidase domain containing 2
NUP85 nucleoporin 85kDa
ORC6 origin recognition complex, subunit 6
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
RACGAP1 Rac GTPase activating protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
STK32B serine/threonine kinase 32B
STMN1 stathmin 1
STX4 syntaxin 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCERG1 transcription elongation regulator 1
TCF4 transcription factor 4
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1