BRD-A75409952_wortmannin_NCIH596_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-A75409952_wortmannin_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRG1 adhesion G protein-coupled receptor G1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANGPT2 angiopoietin 2
ANK2 ankyrin 2, neuronal
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CERS6 ceramide synthase 6
CLC Charcot-Leyden crystal galectin
CXCL12 chemokine (C-X-C motif) ligand 12
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DUSP4 dual specificity phosphatase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM69A family with sequence similarity 69, member A
FN1 fibronectin 1
GAGE3 G antigen 3
GATA2 GATA binding protein 2
GLUL glutamate-ammonia ligase
GRN granulin
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPG2 heparan sulfate proteoglycan 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL17RB interleukin 17 receptor B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRP1 neuropilin 1
PEG10 paternally expressed 10
PLAGL1 pleiomorphic adenoma gene-like 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RBP4 retinol binding protein 4, plasma
RNF167 ring finger protein 167
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERINC3 serine incorporator 3
SLC38A2 solute carrier family 38, member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLN sarcolipin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPP1 tripeptidyl peptidase I
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AMD1 adenosylmethionine decarboxylase 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
CCND3 cyclin D3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
GGT1 gamma-glutamyltransferase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSPA1A heat shock 70kDa protein 1A
ISG20 interferon stimulated exonuclease gene 20kDa
KLK11 kallikrein-related peptidase 11
KRT17 keratin 17, type I
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MYLK myosin light chain kinase
NEFH neurofilament, heavy polypeptide
OAT ornithine aminotransferase
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
RPP25 ribonuclease P/MRP 25kDa subunit
S100A10 S100 calcium binding protein A10
SFN stratifin
SORD sorbitol dehydrogenase
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)