BRD-A75409952_wortmannin_LOVO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A75409952_wortmannin_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CERS6 ceramide synthase 6
CLIC4 chloride intracellular channel 4
CLIP2 CAP-GLY domain containing linker protein 2
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
FRY furry homolog (Drosophila)
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
GSTZ1 glutathione S-transferase zeta 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
MAP2K5 mitogen-activated protein kinase kinase 5
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST2 microtubule associated serine/threonine kinase 2
MBNL1 muscleblind-like splicing regulator 1
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
MT1M metallothionein 1M
MTCH1 mitochondrial carrier 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLIN2 perilipin 2
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
SCAMP1 secretory carrier membrane protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC31A SEC31 homolog A (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TANK TRAF family member-associated NFKB activator
TPBG trophoblast glycoprotein
TRPS1 trichorhinophalangeal syndrome I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WIPI1 WD repeat domain, phosphoinositide interacting 1
WISP2 WNT1 inducible signaling pathway protein 2
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP3 aquaporin 3 (Gill blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CD2 CD2 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKLF chemokine-like factor
CNN1 calponin 1, basic, smooth muscle
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
DPT dermatopontin
DUOX2 dual oxidase 2
EBNA1BP2 EBNA1 binding protein 2
EGR2 early growth response 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FGL2 fibrinogen-like 2
FKBP11 FK506 binding protein 11, 19 kDa
FYB FYN binding protein
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
HSPB8 heat shock 22kDa protein 8
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGKV1-5 immunoglobulin kappa variable 1-5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1RN interleukin 1 receptor antagonist
IPO13 importin 13
ITK IL2-inducible T-cell kinase
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MYCBP MYC binding protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
PCCB propionyl CoA carboxylase, beta polypeptide
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRDX2 peroxiredoxin 2
PSPH phosphoserine phosphatase
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SEPT6 septin 6
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNAI2 snail family zinc finger 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1A small proline-rich protein 1A
SRSF7 serine/arginine-rich splicing factor 7
TDG thymine-DNA glycosylase
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TLR4 toll-like receptor 4
TPD52L1 tumor protein D52-like 1
UBE3C ubiquitin protein ligase E3C
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR61 WD repeat domain 61