BRD-A75301702_-666_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-A75301702_-666_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDOC aldolase C, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C14ORF1 chromosome 14 open reading frame 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NRCAM neuronal cell adhesion molecule
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTS neurotensin
PGD phosphogluconate dehydrogenase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TM7SF2 transmembrane 7 superfamily member 2
TSC22D3 TSC22 domain family, member 3
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ARMCX2 armadillo repeat containing, X-linked 2
CA2 carbonic anhydrase II
CD8A CD8a molecule
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
CST7 cystatin F (leukocystatin)
G0S2 G0/G1 switch 2
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HES1 hes family bHLH transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNMT histamine N-methyltransferase
IDO1 indoleamine 2,3-dioxygenase 1
LGALS8 lectin, galactoside-binding, soluble, 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
PTHLH parathyroid hormone-like hormone
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
SELENBP1 selenium binding protein 1
SRGN serglycin
TDO2 tryptophan 2,3-dioxygenase
TSPAN12 tetraspanin 12
TXN thioredoxin