BRD-A75301702_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-A75301702_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
CALD1 caldesmon 1
CD24 CD24 molecule
CD47 CD47 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CST1 cystatin SN
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
MAP1B microtubule-associated protein 1B
MGLL monoglyceride lipase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODAM odontogenic, ameloblast asssociated
OSBPL10 oxysterol binding protein-like 10
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
VIM vimentin
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
AQP1 aquaporin 1 (Colton blood group)
BTG3 BTG family, member 3
C20ORF24 chromosome 20 open reading frame 24
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CYCS cytochrome c, somatic
FASTKD5 FAST kinase domains 5
FBXL12 F-box and leucine-rich repeat protein 12
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
ITM2C integral membrane protein 2C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PRDX2 peroxiredoxin 2
RGS1 regulator of G-protein signaling 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
TGFBR3 transforming growth factor, beta receptor III
THAP11 THAP domain containing 11