BRD-A75301702_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A75301702_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTG1 B-cell translocation gene 1, anti-proliferative
CANT1 calcium activated nucleotidase 1
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR7 chemokine (C-C motif) receptor 7
CD8A CD8a molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA1 chloride channel accessory 1
CLEC5A C-type lectin domain family 5, member A
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
DAAM1 dishevelled associated activator of morphogenesis 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA5 defensin, alpha 5, Paneth cell-specific
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
EPHB2 EPH receptor B2
FADS2 fatty acid desaturase 2
FBN2 fibrillin 2
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FSCN1 fascin actin-bundling protein 1
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
IPO13 importin 13
KDM5D lysine (K)-specific demethylase 5D
KIAA0226L KIAA0226-like
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MCOLN1 mucolipin 1
MMP1 matrix metallopeptidase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOX1 NADPH oxidase 1
OLFM4 olfactomedin 4
PCCA propionyl CoA carboxylase, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB4 phospholipase C, beta 4
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPRO protein tyrosine phosphatase, receptor type, O
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRY2 sprouty homolog 2 (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
C1QBP complement component 1, q subcomponent binding protein
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNF cyclin F
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CHPT1 choline phosphotransferase 1
CNOT7 CCR4-NOT transcription complex, subunit 7
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
ETFB electron-transfer-flavoprotein, beta polypeptide
F12 coagulation factor XII (Hageman factor)
FAM134B family with sequence similarity 134, member B
GRWD1 glutamate-rich WD repeat containing 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEBP1 heme binding protein 1
HIST1H4C histone cluster 1, H4c
HLF hepatic leukemia factor
HOXC10 homeobox C10
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFITM2 interferon induced transmembrane protein 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MELK maternal embryonic leucine zipper kinase
MYH10 myosin, heavy chain 10, non-muscle
NOLC1 nucleolar and coiled-body phosphoprotein 1
PLAC8 placenta-specific 8
PROM1 prominin 1
RNF167 ring finger protein 167
RRM1 ribonucleotide reductase M1
SCP2 sterol carrier protein 2
SELT selenoprotein T
SET SET nuclear proto-oncogene
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMC1A structural maintenance of chromosomes 1A
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRPRB signal recognition particle receptor, B subunit
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF4 transmembrane 4 L six family member 4
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TUBB tubulin, beta class I
UBA1 ubiquitin-like modifier activating enzyme 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase
USP9X ubiquitin specific peptidase 9, X-linked
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein