BRD-A75144621_digoxin_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-A75144621_digoxin_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CCP110 centriolar coiled coil protein 110kDa
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK6 cyclin-dependent kinase 6
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CLDN8 claudin 8
CLDND1 claudin domain containing 1
COL11A1 collagen, type XI, alpha 1
CST6 cystatin E/M
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DLC1 DLC1 Rho GTPase activating protein
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FGF9 fibroblast growth factor 9
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HOXC10 homeobox C10
IER2 immediate early response 2
IER3 immediate early response 3
IL6 interleukin 6
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT4 keratin 4, type II
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDPR serum deprivation response
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBD thrombomodulin
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM87A transmembrane protein 87A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
C6ORF62 chromosome 6 open reading frame 62
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
COL4A6 collagen, type IV, alpha 6
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF5 eukaryotic translation initiation factor 5
FBXW2 F-box and WD repeat domain containing 2
FHL1 four and a half LIM domains 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA12 melanoma antigen family A12
MBOAT7 membrane bound O-acyltransferase domain containing 7
MUC16 mucin 16, cell surface associated
OXTR oxytocin receptor
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
PRUNE2 prune homolog 2 (Drosophila)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RNASET2 ribonuclease T2
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORBS3 sorbin and SH3 domain containing 3
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
TDO2 tryptophan 2,3-dioxygenase
TRAK2 trafficking protein, kinesin binding 2
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB38 zinc finger and BTB domain containing 38
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZDHHC6 zinc finger, DHHC-type containing 6