BRD-A73741725_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A73741725_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C2 aldo-keto reductase family 1, member C2
APOA1 apolipoprotein A-I
BAG2 BCL2-associated athanogene 2
CALD1 caldesmon 1
CCND2 cyclin D2
CES1 carboxylesterase 1
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
ELOVL5 ELOVL fatty acid elongase 5
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
EXOSC4 exosome component 4
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGKC immunoglobulin kappa constant
IRS2 insulin receptor substrate 2
KANK1 KN motif and ankyrin repeat domains 1
KIAA0355 KIAA0355
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KLHL21 kelch-like family member 21
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRDX2 peroxiredoxin 2
PTPRF protein tyrosine phosphatase, receptor type, F
RAB27A RAB27A, member RAS oncogene family
RBKS ribokinase
SCP2 sterol carrier protein 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ALOX5 arachidonate 5-lipoxygenase
ANXA10 annexin A10
ARL4C ADP-ribosylation factor-like 4C
ASCL1 achaete-scute family bHLH transcription factor 1
BGN biglycan
CALML3 calmodulin-like 3
CD200 CD200 molecule
CFH complement factor H
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
ENG endoglin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXO21 F-box protein 21
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FST follistatin
GATA3 GATA binding protein 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
MEIS2 Meis homeobox 2
NPTX2 neuronal pentraxin II
PADI2 peptidyl arginine deiminase, type II
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PTPRE protein tyrosine phosphatase, receptor type, E
PYCARD PYD and CARD domain containing
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SHB Src homology 2 domain containing adaptor protein B
SNX7 sorting nexin 7
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TMSB15B thymosin beta 15B
TYRP1 tyrosinase-related protein 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VASH1 vasohibin 1
VSIG4 V-set and immunoglobulin domain containing 4
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein
ZNF264 zinc finger protein 264