BRD-A72703248_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-A72703248_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BIK BCL2-interacting killer (apoptosis-inducing)
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL9A2 collagen, type IX, alpha 2
EPAS1 endothelial PAS domain protein 1
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IPO13 importin 13
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG1 jagged 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLXNB2 plexin B2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTBP2 polypyrimidine tract binding protein 2
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERINC5 serine incorporator 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
SUSD4 sushi domain containing 4
TGFA transforming growth factor, alpha
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM2 tripartite motif containing 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
XCL1 chemokine (C motif) ligand 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BACE2 beta-site APP-cleaving enzyme 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHEK2 checkpoint kinase 2
CHPT1 choline phosphotransferase 1
CRTAP cartilage associated protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
GATA3 GATA binding protein 3
GPC3 glypican 3
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HLTF helicase-like transcription factor
HOXC6 homeobox C6
KIAA0101 KIAA0101
KIF2C kinesin family member 2C
LACTB2 lactamase, beta 2
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LDHB lactate dehydrogenase B
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MSRB2 methionine sulfoxide reductase B2
MUC1 mucin 1, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYH10 myosin, heavy chain 10, non-muscle
NOTCH2 notch 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PTGES prostaglandin E synthase
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
SEPP1 selenoprotein P, plasma, 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SRSF1 serine/arginine-rich splicing factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TIMP4 TIMP metallopeptidase inhibitor 4
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBL3 ubiquitin-like 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XBP1 X-box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZWINT ZW10 interacting kinetochore protein